https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54520 5% O2. Through the generation of a germline-specific Epas1 knockout mouse line, and through modulation of EPAS1 levels in primary cultures of spermatogonia with the small drug molecule Daprodustat, we have demonstrated that EPAS1 is required for robust SSC function in regenerative conditions (post-transplantation and post-chemotherapy), via the regulation of key cellular processes such as metabolism. These findings shed light on the relationship between hypoxia and male fertility and will potentially facilitate optimization of in vitro culture conditions for infertility treatment pipelines using SSCs, such as those directed at pediatric cancer survivors.]]> Wed 28 Feb 2024 16:12:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26760 Wed 17 Mar 2021 09:57:51 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29816 Wed 11 Apr 2018 16:12:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15688 Wed 11 Apr 2018 16:09:19 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24826 0.05) in HOT and HYP and only decreased in HH (-8%) compared with CON. Body mass (-2%), temperatures (+2-5%), and TS (+18%) were altered in HOT. Furthermore, SₐO₂ (-8%) and HR (+3%) were changed in HYP. Similar changes in body mass and temperatures, HR, TS, and SₐO₂ were evident in HH to HOT and HYP, however, blood lactate (p < 0.001) and plasma volume (p < 0.001) were only significantly altered in HH. Perceived exertion was elevated (p < 0.05) by 7% in all conditions compared with CON. Regression analysis identified that absolute TS and absolute rise in skin and estimated muscle temperature (r = 0.82, r = 0.84 r = 0.82, respectively; p < 0.05) predicted the hot-mediated-decrements in HOT. The hot, hypoxic, and hot-hypoxic environments impaired physical performance during iSPT. Future interventions should address the increases in TS and body temperatures, to attenuate these decrements on soccer performance.]]> Wed 11 Apr 2018 16:07:36 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22789 Wed 11 Apr 2018 14:49:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7309 Wed 11 Apr 2018 11:20:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24444 Wed 11 Apr 2018 10:16:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:29979 Wed 04 Sep 2019 10:18:53 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34448 Wed 04 Sep 2019 09:56:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38036 Tue 27 Jul 2021 15:08:13 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53287 Tue 21 Nov 2023 10:23:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23703 Tue 18 Oct 2016 15:56:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36359 Thu 28 Oct 2021 13:03:11 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:665 Thu 25 Jul 2013 09:10:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48127 Thu 02 Mar 2023 15:41:40 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9606 Sat 24 Mar 2018 08:39:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12732 Sat 24 Mar 2018 08:18:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12675 Sat 24 Mar 2018 08:15:41 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:10574 Sat 24 Mar 2018 08:10:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20954 Sat 24 Mar 2018 08:06:08 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20571 Sat 24 Mar 2018 08:02:38 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21764 –1) from 0–72 h postfertilization (hpf), a developmental window when steroidogenesis is unregulated by pituitary influence, resulted in the up-regulation of cyp11a, cyp17, and 3β-hsd and the down-regulation of cyp19a. Similar gene expression patterns were observed for embryos exposed to 10 mM cobalt chloride (CoCl₂, a chemical inducer of hypoxia-inducible factor 1, HIF-1), suggesting a regulatory role of HIF-1 in steroidogenesis. Testosterone (T) and estradiol (E2) concentrations in hypoxic embryos were greater and lesser, respectively, relative to the normoxic control, thus leading to an increased T/E2 ratio. Expression of the leptin-a gene (zlep-a) was up-regulated upon both hypoxia and CoCl₂ treatments. Functional assays suggested that under hypoxia, elevated zlep-a expression might activate cyp11a and 3β-hsd and inhibit cyp19a. Overall, this study indicates that hypoxia, possibly via HIF-1-induced leptin expression, modulates sex steroid synthesis by acting directly on steroidogenic gene expression.]]> Sat 24 Mar 2018 07:53:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:136 Sat 24 Mar 2018 07:43:14 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27283 Sat 24 Mar 2018 07:40:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26796 IO₂] 0.21), moderate-level hypoxia (F _IO₂ 0.16), or high-level hypoxia (F_IO₂ 0.13) by a portable hypoxic unit. Peak and mean force and power variables were monitored during exercise. Arterial oxygen saturation (SpO₂), heart rate (HR), and rating of perceived exertion (RPE) were assessed immediately following each set. No differences in force or power variables were evident between conditions. Similar trends were evident in these variables across each set and across the exercise session in each condition. SpO₂ was lower in hypoxic conditions than in NORM, whereas HR was higher following sets performed in hypoxia. There were no differences between conditions in RPE. These results indicate that a hypoxic stimulus during high-intensity resistance exercise does not alter physical performance during repetitions and sets or affect how strenuous exercise is perceived to be. This novel training strategy can be used without adversely affecting the physical training dose experienced and may provide benefits over the equivalent training in NORM.]]> Sat 24 Mar 2018 07:36:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50299 Sat 15 Jul 2023 12:18:12 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47387 Mon 16 Jan 2023 15:31:37 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:52306 Mon 09 Oct 2023 10:16:43 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13808 Mon 08 Apr 2019 14:44:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53126 Fri 17 Nov 2023 12:21:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40046 Fri 15 Jul 2022 10:05:42 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34698 75% of its contraction capability. The effects of resveratrol on uterine contractions under hypoxia were attenuated by tetraethylammonium (10 mM) and almost abolished by glibenclamide (10 µM). Our results show regenerative and protective effects of resveratrol in non-pregnant murine uteri under hypoxia and describes for the first time that these effects are mediated by blockade of ATP-sensitive potassium channels.]]> Fri 12 Apr 2019 15:45:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30102 Fri 11 Jun 2021 13:30:23 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55287 Fri 10 May 2024 16:22:11 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54686 Fri 08 Mar 2024 11:53:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41557  100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55–100 mmHg) patients (P = 0.47). Conclusions; Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort.]]> Fri 05 Aug 2022 14:30:30 AEST ]]>